Besides cystoid macular edema due to a blood-retinal barrier breakdown, another type of
macular cystoid spaces referred to as non-vasogenic cystoid maculopathies (NVCM) may be …

The dark-adapted human electroretinogram (ERG) response to a standard bright flash
includes a negative-going a-wave followed by a positive-going b-wave that crosses the …

PURPOSE To analyze the clinical characteristics, natural history, and genetics of CRB1-
associated retinal dystrophies. DESIGN Multicenter international retrospective cohort study …

Purpose To describe the phenotype, long-term clinical course, clinical variability, and
genotype of patients with CRB1-associated retinal dystrophies. Design Retrospective cohort …

PURPOSE To investigate the natural disease course of retinal dystrophies associated with
crumbs cell polarity complex component 1 (CRB1) and identify clinical end points for future …

To date, over 150 disease-associated variants in CRB1 have been described, resulting in a
range of retinal disease phenotypes including Leber congenital amaurosis and retinitis …

Once considered science fiction, gene therapy is rapidly becoming scientific reality, targeting
a growing number of the approximately 250 genes linked to hereditary retinal disorders such …

The Crumbs complex has prominent roles in the control of apical cell polarity, in the coupling
of cell density sensing to downstream cell signaling pathways, and in regulating junctional …

Loss of Crumbs homolog 1 (CRB1) or CRB2 proteins in Müller cells or photoreceptors in the
mouse retina results in a CRB dose-dependent retinal phenotype. In this study, we present a …

The mammalian apical-basal determinant Crumbs homolog-1 (CRB1) plays a crucial role in
retinal structure and function by the maintenance of adherens junctions between …