Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

The principles of managing patients suffering from hemorrhagic shock have evolved over
time. It is well supported that patients who continue to suffer from shock or hypoperfusion are …

Background After a person has been injured, prehospital administration of plasma in
addition to the initiation of standard resuscitation procedures in the prehospital environment …

Importance In-hospital administration of tranexamic acid after injury improves outcomes in
patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

Irrespective of the cause of cardiac arrest, early recognition and calling for help, including
appropriate management of the deteriorating patient, early defibrillation, high-quality …

Background The resuscitation of severely injured bleeding patients has evolved into a multi-
modal strategy termed damage control resuscitation (DCR). This guideline evaluates …

Background: Massive transfusion protocols (MTPs) have become standard of care in the
management of bleeding injured patients, yet strategies to guide them vary widely. We …