Heart disease and stroke statistics—2023 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2023 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association

SS Martin, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases

R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

The COVID-19 pandemic and Alzheimer's disease: mutual risks and mechanisms

F Chen, Y Chen, Y Wang, Q Ke, L Cui - Translational neurodegeneration, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially …

[HTML][HTML] The world goes bats: living longer and tolerating viruses

V Gorbunova, A Seluanov, BK Kennedy - Cell Metabolism, 2020 - cell.com
For centuries, people believed that bats possessed sinister powers. Bats are thought to be
ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most …

The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study

A Gharbi-Meliani, A Dugravot, S Sabia, M Regy… - Alzheimer's research & …, 2021 - Springer
Background Approximately 25% of the general population carries at least one ε4 allele of
the Apolipoprotein E (APOE ε4), the strongest genetic risk factor for late onset Alzheimer's …

Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample

MS Naslavsky, CK Suemoto, LA Brito, MO Scliar… - Molecular …, 2022 - nature.com
Dementia is more prevalent in Blacks than in Whites, likely due to a combination of
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …

Genomics in personalized nutrition: can you “eat for your genes”?

VA Mullins, W Bresette, L Johnstone, B Hallmark… - Nutrients, 2020 - mdpi.com
Genome-wide single nucleotide polymorphism (SNP) data are now quickly and
inexpensively acquired, raising the prospect of creating personalized dietary …

[HTML][HTML] Alzheimer's Disease as A Viral Infectious Disease: Revisiting the Infectious Hypothesis

F Bruno, P Abondio, R Bruno, L Ceraudo… - Ageing research …, 2023 - Elsevier
Alzheimer's disease (AD) represents the most frequent type of dementia in elderly people.
Two major forms of the disease exist: sporadic-the causes of which have not yet been fully …

APOE Alleles and Diet in Brain Aging and Alzheimer's Disease

HN Yassine, CE Finch - Frontiers in aging neuroscience, 2020 - frontiersin.org
The APOE gene alleles modify human aging and the response to the diet at many levels
with diverse pleotropic effects from gut to brain. To understand the interactions of APOE …