Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

Within the last decade, the application range of aptamers in biochemistry and medicine has
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …

Biological nanopores are nanoscale sensors employed for high-throughput, low-cost, and
long read-length DNA sequencing applications. The analysis and sequencing of proteins …

Sensitivity and specificity are two most important factors to take into account for molecule
sensing, chemical detection and disease diagnosis. A perfect sensitivity is to reach the level …

In contrast to B-DNA that has a right-handed double helical structure with Watson–Crick
base pairing under the ordinary physiological conditions, repetitive DNA sequences under …

Foodborne diseases, caused by pathogenic bacteria, severely threaten global human health
and cause a financial burden. Rapid, sensitive and on-site detection of pathogenic bacteria …

Protein nanopores have been used as stochastic sensors for the detection of analytes that
range from small molecules to proteins. In this approach, individual analyte molecules …

The duplex formation mediated by Hg2+ in a properly designed ssDNA generates a stable
hairpin structure, which greatly alters the translocation profile of the ssDNA through α …

Highly specific and tight-binding nucleic acid aptamers have been selected against a variety
of molecular targets for over 20 years. A significant proportion of these oligonucleotides …

Molecular-scale pore structures, called nanopores, can be assembled by protein ion
channels through genetic engineering or be artificially fabricated on solid substrates using …