Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Introduction Four different genetic families of the enzyme carbonic anhydrase (CA, EC 4.2.
1.1) are present in bacteria, α-, β-, γ-and ι-CAs. They play relevant functions related to CO2 …

The universal rise in the outbreak and fatality rates related to multidrug-resistant
microorganisms is a growing problem worldwide that necessitates the emergence of new …

Carbonic anhydrases, catalysing the reversible CO2 hydration reaction, contribute in all
living organisms to the maintenance of stable metabolic functions depending on intracellular …

Click chemistry reactions constitute an important and relatively new approach in the
medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms …

Carbonic anhydrases (CAs) from the pathogenic bacteria Nesseria gonorrhoeae and
vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug …

The α-class carbonic anhydrases (CAs, EC 4.2. 1.1) from the bacterial pathogens Neisseria
gonorrhoeae (NgCAα) and Vibrio cholerae (VchCAα) were investigated for their inhibition by …

Isocoumarins, isomeric to comarins which act as effective carbonic anhydrase (CA, EC 4.2.
1.1) inhibitors, were investigated for the first time as inhibitors of this enzyme. A series of 3 …

Introduction Neisseria gonorrhoeae is a common sexually transmitted disease connected
with extensive drug resistance to many antibiotics. Presently, only expanded spectrum …

Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis
(MTB) and a significant health concern worldwide. The main threat to the elimination of TB is …