Beneficial effects of citrus flavonoids on cardiovascular and metabolic health

AM Mahmoud, RJ Hernandez Bautista… - Oxidative medicine …, 2019 - Wiley Online Library
The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a
comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess …

Microvesicles: ROS scavengers and ROS producers

G Bodega, M Alique, L Puebla… - Journal of …, 2019 - Taylor & Francis
This review analyzes the relationship between microvesicles and reactive oxygen species
(ROS). This relationship is bidirectional; on the one hand, the number and content of …

[HTML][HTML] Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants

RJH Bautista, AM Mahmoud, M Königsberg… - Biomedicine & …, 2019 - Elsevier
Obesity and overweight have increased at an alarming rate in the world during the last three
decades. Obesity is a crucial factor in the development of metabolic abnormalities, including …

[HTML][HTML] Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy

AM Al Hroob, MH Abukhalil, RD Alghonmeen… - Biomedicine & …, 2018 - Elsevier
Oxidative stress plays a major role in the development and progression of diabetic
nephropathy (DN). In this study, the potential protective effect of ginger (Zingiber officinale) …

Galangin activates Nrf2 signaling and attenuates oxidative damage, inflammation, and apoptosis in a rat model of cyclophosphamide-induced hepatotoxicity

SH Aladaileh, MH Abukhalil, SAM Saghir, H Hanieh… - Biomolecules, 2019 - mdpi.com
Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical
application is limited because of its multi-organ toxicity. Galangin (Gal) is a bioactive …

Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy

OY Althunibat, AM Al Hroob, MH Abukhalil… - Life sciences, 2019 - Elsevier
Aims Hyperglycemia-mediated oxidative damage has been described as a major
mechanism leading to pathologic changes associated with diabetic cardiomyopathy (DCM) …

[HTML][HTML] Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats

MH Abukhalil, OY Althunibat, SH Aladaileh… - Biomedicine & …, 2021 - Elsevier
Cardiovascular complications are the leading cause of morbidity in diabetes. Oxidative
stress and inflammation are implicated in the development and progression of diabetic …

Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis

AM Mahmoud, OE Hussein, SM Abd El-Twab… - Food & Function, 2019 - pubs.rsc.org
Drug-induced nephrotoxicity contributes to acute kidney injury (AKI) and represents a major
problem in the clinical setting. We investigated the possible involvement of NLRP3 …

Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats

AM Mahmoud, WG Hozayen, SM Ramadan - Biomedicine & …, 2017 - Elsevier
Berberine (BBR) is a natural isoquinoline alkaloid with very impressive health benefits. It is
one of the most effective natural supplements available; however, its ameliorative …

[HTML][HTML] Olea europaea leaf extract up-regulates Nrf2/ARE/HO-1 signaling and attenuates cyclophosphamide-induced oxidative stress, inflammation and apoptosis in …

HAS ALHaithloul, MF Alotaibi, M Bin-Jumah… - Biomedicine & …, 2019 - Elsevier
Olive leaf extract (OLE) has potential health benefits and protects against cytotoxicity in
different organs. However, nothing has yet been reported on its potential to prevent …