Molecular mechanisms of the antitumor effects of mesalazine and its preventive potential in colorectal cancer

J Słoka, M Madej, B Strzalka-Mrozik - Molecules, 2023 - mdpi.com
Chemoprevention is one of the ways to fight colorectal cancer, which is a huge challenge in
oncology. Numerous pieces of evidence indicate that chronic inflammation in the course of …

Oxidative stress and inducible nitric oxide synthase induction in carcinogenesis

F Farinati, M Piciocchi, E Lavezzo, M Bortolami… - Digestive …, 2010 - karger.com
Background: Chronic inflammation is linked to an increased risk of cancer. The molecular
mechanisms underlying this correlation have been long investigated and it is well known …

Astragalus membranaceus Extract Attenuates Inflammation and Oxidative Stress in Intestinal Epithelial Cells via NF-κB Activation and Nrf2 Response

S Adesso, R Russo, A Quaroni, G Autore… - International Journal of …, 2018 - mdpi.com
Astragalus membranaceus, dried root extract, also known as Astragali radix, is used in
traditional Chinese medicine as a tonic remedy. Moreover, it has been reported that …

Brain-derived neurotrophic factor/tropomyosin-related kinase B pathway in gastric cancer

Y Okugawa, K Tanaka, Y Inoue, M Kawamura… - British journal of …, 2013 - nature.com
Background: Brain-derived neutrophic factor (BDNF) is a member of the neutrophin family
that is known to activate the high-affinity tropomyosin-related receptor kinase B (TrkB). This …

Antiangiogenic activity of berberine is mediated through the downregulation of hypoxia-inducible factor-1, VEGF, and proinflammatory mediators

TP Hamsa, G Kuttan - Drug and Chemical Toxicology, 2012 - Taylor & Francis
Berberine, a naturally occurring isoquinoline alkaloid, is present in a number of important
medicinal plants. Berberine has a wide range of biochemical and pharmacological effects …

Pro-Inflammatory Effects of Indoxyl Sulfate in Mice: Impairment of Intestinal Homeostasis and Immune Response

SF Rapa, F Prisco, A Popolo, V Iovane… - International Journal of …, 2021 - mdpi.com
The intestines are recognized as the main source of chronic inflammation in chronic kidney
disease (CKD) and, among other cells, macrophages are involved in modulating this …

Prospects of new targeted nanotherapy combining liponiosomes with berberine to combat colorectal cancer development: An in vivo experimental model

D Ibrahim, SI Khater, A Abdelfattah-Hassan… - International Journal of …, 2023 - Elsevier
Colorectal cancer (CRC) is one of the most identified and deadly malignancies worldwide. It
presents a serious challenge due to its quick growth, which finally culminates in severe …

Inflamed leukocyte-mimetic nanoparticles for molecular imaging of inflammation

X Chen, R Wong, I Khalidov, AY Wang… - Biomaterials, 2011 - Elsevier
Dysregulated host inflammatory response causes many diseases, including cardiovascular
and neurodegenerative diseases, cancer, and sepsis. Sensitive detection of the site of …

Anti-inflammatory activity of horseradish (Armoracia rusticana) root extracts in LPS-stimulated macrophages

S Marzocco, L Calabrone, S Adesso, M Larocca… - Food & Function, 2015 - pubs.rsc.org
Horseradish (Armoracia rusticana) is a perennial crop belonging to the Brassicaceae family.
Horseradish root is used as a condiment due to its extremely pungent flavour, deriving from …

[HTML][HTML] Bone marrow cell therapy on 1, 2-dimethylhydrazine (DMH)-induced colon cancer in rats

MF El-Khadragy, HM Nabil, BN Hassan… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Stem cell based therapies are being under focus due to their possible
role in treatment of various tumors. Bone marrow stem cells believed to have anticancer …