Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to
embryonic stem cells, such as the capacity of self-renewal and differentiation into many …

Mutations of Lamin A/C gene (LMNA) cause laminopathies, a group of disorders associated
with a wide spectrum of clinically distinct phenotypes, affecting different tissues and organs …

Mutations in LMNA, which encodes the nuclear proteins Lamin A/C, can cause
cardiomyopathy and conduction disorders. Here, we employ induced pluripotent stem cells …

During the last two decades, significant progress has been made in the identification of
genetic defects underlying inherited arrhythmia syndromes, which has provided some …

Relevant, predictive normal, or disease model systems are of vital importance for drug
development. The difference between nonhuman models and humans could contribute to …

Technical advances in generating and phenotyping cardiomyocytes from human pluripotent
stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to …

It is now a decade since human induced pluripotent stem cells (hiPSCs) were first described.
The reprogramming of adult somatic cells to a pluripotent state has become a robust …

Hyper-activation of extracellular signal-regulated kinase (ERK) 1/2 contributes to heart
dysfunction in cardiomyopathy caused by mutations in the lamin A/C gene (LMNA …

Vagus nerve stimulation (VNS) restores autonomic balance, suppresses inflammation action
and minimizes cardiomyocyte injury. However, little knowledge is known about the VNS'role …

In the past few years, the use of specific cell types derived from induced pluripotent stem
cells (iPSCs) has developed into a powerful approach to investigate the cellular …