[HTML][HTML] Nucleosidic DNA demethylating epigenetic drugs–a comprehensive review from discovery to clinic
DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic
silencing of cancer-related genes. Since the relationship between aberrant DNA methylation …
silencing of cancer-related genes. Since the relationship between aberrant DNA methylation …
[图书][B] Medicinal chemistry of anticancer drugs
C Avendaño, JC Menéndez - 2015 - books.google.com
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment
from the point of view of medicinal chemistry and drug design, focusing on the mechanism of …
from the point of view of medicinal chemistry and drug design, focusing on the mechanism of …
Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX
J Dvořanová, M Kugler, J Holub, V Šícha, V Das… - European Journal of …, 2020 - Elsevier
Abstract Carbonic anhydrase IX (CA IX) is a transmembrane enzyme overexpressed in
hypoxic tumors, where it plays an important role in tumor progression. Specific CA IX …
hypoxic tumors, where it plays an important role in tumor progression. Specific CA IX …
Targeting an inducible SALL4-mediated cancer vulnerability with sequential therapy
Oncofetal protein SALL4 is critical for cancer cell survival. Targeting SALL4, however, is only
applicable in a fraction of cancer patients who are positive for this gene. To overcome this …
applicable in a fraction of cancer patients who are positive for this gene. To overcome this …
Differential regulation of methylation‐regulating enzymes by senescent stromal cells drives colorectal cancer cell response to DNA‐demethylating Epi‐drugs
The advanced‐stage colon cancer spreads from primary tumor site to distant organs where
the colon‐unassociated stromal population provides a favorable niche for the growth of …
the colon‐unassociated stromal population provides a favorable niche for the growth of …
Epigenetics: new possibilities for drug discovery
K Lundstrom - Future Medicinal Chemistry, 2017 - Taylor & Francis
Difficulties in discovery and development of novel drugs based on conventional methods
have accelerated applications of alternative approaches. Automation and miniaturization of …
have accelerated applications of alternative approaches. Automation and miniaturization of …
Induction of a SALL4-dependency for targeted cancer therapy
Oncofetal protein SALL4 is critical for tumor cell survival, making it a promising target in
cancer therapy. However, it is detectable only in a subset of cancer patients, which limits the …
cancer therapy. However, it is detectable only in a subset of cancer patients, which limits the …
Epigenetics, nutrition, disease and drug development
K Lundstrom - Current drug discovery technologies, 2019 - ingentaconnect.com
Epigenetic mechanisms comprising of DNA methylation, histone modifications and gene
silencing by RNA interference have been strongly linked to the development and …
silencing by RNA interference have been strongly linked to the development and …
[PDF][PDF] Reporter based DNA demethylation detection system
K Agrawal - LABORATORY TECHNIQUES IN CELLULAR AND …, 2021 - researchgate.net
CpG island hypermethylation causing gene silencing is well evident in cancers, and various
other disease types. Despite major advances in the field of epigenetic research, the success …
other disease types. Despite major advances in the field of epigenetic research, the success …
[PDF][PDF] Faculty of Medicine and Dentistry
K Agrawal - 2017 - researchgate.net
DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic
silencing of cancer-related genes. Since the relationship between aberrant DNA methylation …
silencing of cancer-related genes. Since the relationship between aberrant DNA methylation …