Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …

Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical
or radiation treatment of primary tumours,~ 50% of patients progress to metastatic disease …

Chromosome biorientation on the mitotic spindle is prerequisite to errorless genome
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …

In metazoans, a≈ 1 megadalton (MDa) multiprotein complex comprising the dynein–
dynactin adaptor Spindly and the ROD–Zwilch–ZW10 (RZZ) complex is the building block of …

Chromosome alignment and biorientation is essential for mitotic progression and genomic
stability. Most chromosomes align at the spindle equator in a motor-independent manner …

Protein lipidations are vital co/post-translational modifications that tether lipid tails to specific
protein amino acids, allowing them to anchor to biological membranes, switch their …

Abstract 53BP1 acts at the crossroads between DNA repair and p53‐mediated stress
response. With its interactors p53 and USP28, it is part of the mitotic surveillance (or mitotic …

Accurate chromosome segregation is required for cell survival and organismal development.
During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high …

Error-free mitosis depends on accurate chromosome attachment to spindle microtubules,
powered congression of those chromosomes, their segregation in anaphase, and assembly …