The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

Although mutations in mitochondrial-associated genes are linked to inflammation and
susceptibility to infection, their mechanistic contributions to immune outcomes remain ill …

Multicellular organisms live in environments containing diverse nutrients and a wide variety
of microbial communities. On the one hand, the immune response of organisms can protect …

Aging is characterized by a decline in tissue function, but the underlying changes at cellular
resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a …

The immune response is an energy‐demanding process that must be coordinated with
systemic metabolic changes redirecting nutrients from stores to the immune system …

Tumor-induced host wasting and mortality are general phenomena across species. Many
groups have previously demonstrated endocrinal impacts of malignant tumors on host …

Organs have a distinctive yet often overlooked spatial arrangement in the body,,,–. We
propose that there is a logic to the shape of an organ and its proximity to its neighbours …

An active immune response is energetically demanding and requires reallocation of
nutrients to support resistance to and tolerance of infection. Insulin signaling is a critical …

Insects are critical to our ecosystems, but we do not fully understand their future in our
warming world. Rising temperatures are affecting insect physiology in myriad ways …

Intestinal stem cells (ISCs) decode and coordinate various types of nutritional information
from the diet to support the crypt–villus axis architecture, but how specific dietary molecules …