Site-specific protein modification is a widely-used biochemical tool. However, there are
many challenges associated with the development of protein modification techniques, in …

The surface of Gram-positive and Gram-negative bacteria contains long hair-like
proteinaceous protrusion known as pili or fimbriae. Historically, pilin proteins were …

Frontotemporal lobar degeneration (FTLD) is the third most common neurodegenerative
condition after Alzheimer's and Parkinson's diseases. FTLD typically presents in 45 to 64 …

Much of life's complexity depends upon contacts between proteins with precise affinity and
specificity. The successful application of engineered proteins often depends on high-stability …

Chemists, biologists, and material scientists alike have long sought to control protein
presentation, orientation, and activity within biomaterials to dictate reaction catalysis …

Bacteria can be programmed to create engineered living materials (ELMs) with self-healing
and evolvable functionalities. However, further development of ELMs is greatly hampered by …

Enzymes are powerful tools for protein labelling due to their specificity and mild reaction
conditions. Many protocols, however, are restricted to modifications at protein termini, rely on …

Sortase A (SrtA)‐mediated ligation, a popular method for protein labeling and semi‐
synthesis, is limited by its reversibility and dependence on the LPxTG motif, where “x” is any …

Cell-laden hydrogels whose crosslinking density can be dynamically and reversibly tuned
are highly sought-after for studying pathophysiological cellular fate processes, including …

Sortase‐mediated ligation (SML) has emerged as a powerful and versatile methodology for
site‐specific protein conjugation, functionalization/labeling, immobilization, and design of …