Can activation of NRF2 be a strategy against COVID-19?

A Cuadrado, M Pajares, C Benito… - Trends in …, 2020 - cell.com
Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis …

Hydrogen sulfide biology and its role in cancer

S Khattak, MA Rauf, NH Khan, QQ Zhang, HJ Chen… - Molecules, 2022 - mdpi.com
Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian
tissues. It plays a very critical role in many pathophysiological processes in the body. It can …

Oxidative stress and vascular inflammation in aging

M El Assar, J Angulo, L Rodríguez-Mañas - Free Radical Biology and …, 2013 - Elsevier
Vascular aging, a determinant factor for cardiovascular disease and health status in the
elderly, is now viewed as a modifiable risk factor. Impaired endothelial vasodilation is a early …

Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways

L Bao, J Li, D Zha, L Zhang, P Gao, T Yao… - International …, 2018 - Elsevier
Oxidative and inflammatory damage have been suggested to play important roles in the
pathogenesis of diabetic nephropathy (DN). Chlorogenic acid (CGA) is one of the most …

Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability

H Wang, T Oo Khor, L Shu, ZY Su… - Anti-Cancer Agents …, 2012 - ingentaconnect.com
Cancer remains to be one of the leading causes of death in the United States and around
the world. The advent of modern drug-targeted therapies has undeniably improved cancer …

[HTML][HTML] Sulforaphane: A broccoli bioactive phytocompound with cancer preventive potential

AE Kaiser, M Baniasadi, D Giansiracusa… - Cancers, 2021 - mdpi.com
There is substantial and promising evidence on the health benefits of consuming broccoli
and other cruciferous vegetables. The most important compound in broccoli, glucoraphanin …

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

SC Gupta, JH Kim, S Prasad, BB Aggarwal - Cancer and Metastasis …, 2010 - Springer
Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy
medicine and medicine be thy food.” Exploring the association between diet and health …

Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention

A Kapinova, P Kubatka, O Golubnitschaja… - … health and preventive …, 2018 - Springer
Cancerous tissue transformation developing usually over years or even decades of life is a
highly complex process involving strong stressors damaging DNA, chronic inflammation …

Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis

JV Higdon, B Delage, DE Williams… - Pharmacological …, 2007 - Elsevier
Cruciferous vegetables are a rich source of glucosinolates and their hydrolysis products,
including indoles and isothiocyanates, and high intake of cruciferous vegetables has been …

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

W Li, TO Khor, C Xu, G Shen, WS Jeong, S Yu… - Biochemical …, 2008 - Elsevier
Oxidative stress has been implicated in the etiology of neurodegenerative disease, cancer
and aging. Indeed, accumulation of reactive oxygen and nitrogen species generated by …