Determination of the role of insulin-like growth factor (IGF) family components in
carcinogenesis of several human tumors is based on numerous epidemiological and pre …

Non-small cell lung cancer (NSCLC) remains one of the deadliest malignant diseases, with
high incidence and mortality worldwide. The insulin-like growth factor (IGF) axis, consisting …

The insulin-like growth factor (IGF)-pathway is involved in tumor cell proliferation,
metastasis, and survival. We aimed to find out what effects IGF binding protein 3 (IGFBP3) …

Angiogenesis is essential in the early stage of solid tumor recurrence, but how a suspensive
tumor is reactivated before angiogenesis is mostly unknown. Herein, we stumble across an …

In this study, we examined the roles of heparanase and IGFBP-3 in regulating A549 and
H1299 non-small-cell lung cancer (NSCLC) survival. We found that H1299 cells, known to …

(1) Background: Activation of the PI3K-AKT pathway controls most hallmarks of cancer, and
the hedgehog (HH) pathway has been associated with oral squamous cell carcinoma …

Colon cancer is one of the most common malignancies. Although the current treatment
regimes for colon cancer have been well-developed in the past decades, the prognosis …

Lung cancer is the leading cause of cancer mortality worldwide. Approximately 85% of all
lung cancer cases are classified as non‑small cell lung cancer (NSCLC). Currently, there is …

Metformin, a widely prescribed oral hypoglycemic agent, has recently received a big interest
because of its potential antitumorigenic effects in different cancer types. The present study …

The insulin-like growth factor-1 receptor (IGF-1R) is a central component of lung cancer
signal transduction pathways. A phase III study failed for carboplatin, paclitaxel, with or …