Bacterial resistance mechanisms are continuously and rapidly evolving. This is particularly
true for Gram-negative bacteria. Over the last decade, the strategy to develop new β …

Acute kidney injury represents a common complication in critically ill patients affected by
septic shock and in many cases continuous renal replacement therapy (CRRT) may be …

Since the discovery of penicillin, β-lactam antibiotics have commonly been used to treat
bacterial infections. Unfortunately, at the same time, pathogens can develop resistance to β …

ABSTRACT Introduction Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream
infection (BSI) is a major issue in healthcare, since it is often associated with endocarditis or …

Critically ill patients suffering from severe infections are prone to pathophysiological
pharmacokinetic changes that are frequently associated with inadequate antibiotic serum …

This study was conducted to develop a rapid, simple and reproducible method for the
quantification of ceftaroline in plasma samples by high-performance liquid chromatography …

Background: Currently, the escalation of microbial resistance poses a significant global
challenge. Children are more susceptible to develop infections and therefore are prescribed …

Introduction: Continuous renal replacement therapies (CRRTs) are frequently used in
critically ill patients; however, there are scarce in vitro and in vivo studies showing the …

Computational pharmacokinetic (PK) modeling and simulation are revolutionizing the fields
of drug development and therapeutic use. PK models use mathematical equations to study …

Microbiological, Clinical, and PK/PD Features of the New Anti-Gram-Negative Antibiotics: β-Lactam/β-Lactamase
Inhibitors in Co Page 1 P osted on 14 Dec 2023 — The cop yrigh t holder is the author/funder …