Cancer cells possess a broad spectrum of migration and invasion mechanisms. These
include both individual and collective cell-migration strategies. Cancer therapeutics that are …

▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix
developed by cells in culture. They provide a structural link between the actin cytoskeleton …

Summary c-Jun amino-terminal kinases (JNKs) and mitogen-activatedprotein kinases
(MAPKs) are closely related; however, they are independently regulated by a variety of …

▪ Abstract Members of the Rho family of small Ras-like GTPases—including RhoA,-B, and-C,
Rac1 and-2, and Cdc42—exhibit guanine nucleotide-binding activity and function as …

Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy.
Among the most provocative recent results in DGC has been that of highly recurrent …

Mitogen stimulation of cytoskeletal changes and c-jun amino-terminal kinases is mediated
by Rac small guanine nucleotide-binding proteins. Vav, a guanosine diphosphate (GDP) …

Although substantial evidence supports a critical role for the activation of Raf-1 and mitogen-
activated protein kinases (MAPKs) in oncogenic Ras-mediated transformation, recent …

The GTP hydrolases of the Rho/Rac family participate in the generation of coordinated
cellular responses to extracellular stimuli (52, 153). Their actions are essential to promote …

The field of apoptosis is unusual in several respects. Firstly, its general importance has been
widely recognised only in the past few years and its surprising significance is still being …

Rho, a member of the Ras superfamily of GTP-binding proteins, regulates actin
polymerization resulting in the formation of stress fibers and the assembly of focal …