The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after
cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling …

Rationale: Direct reprogramming of cardiac fibroblasts to cardiomyocytes has recently
emerged as a novel and promising approach to regenerate the injured myocardium. We …

We have recently shown that a combination of microRNAs, miR combo, can directly
reprogram cardiac fibroblasts into functional cardiomyocytes in vitro and in vivo …

Human heart has endogenous regenerative capability; however, the intrinsic repair
mechanism is not sufficient to overcome the impact placed by adverse pathological …

Following heart injury, cardiomyocytes, are lost and are not regenerated. In their place,
fibroblasts invade the dead tissue where they generate a scar, which reduces cardiac …

The standard scaffold-mediated delivery of drugs/biomolecules has been successful due to
the unique attributes of scaffolds, specifically the electrospun polymeric scaffolds that mimic …

Ischemic heart disease is a predominant cause of death worldwide. The loss or death of
cardiomyocytes due to restricted blood flow often results in a cardiac injury. Myofibroblasts …

MicroRNAs (miRNAs) 是一类非编码小分子RNA, 参与调控基因表达, 也是心脏发育的重要调控
者. 人类发育成熟的心脏损伤后再生能力有限, 并且损伤的心肌由大量增殖的成纤维细胞替代 …

Heart diseases are the leading cause of death worldwide. Although surgical interventions
can provide valuable options for treatment, current therapies in cardiovascular medicine …

The invention provides a method of promoting reprogramming of a cardiac fibroblast into a
cardiomyocyte by contacting the cardiac fibroblast with an isolated polynucleotide molecule …