Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. Much of the recognised health-care burden occurs in the minority of people with …

Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past
two decades given their pivotal function in a variety of biological contexts, including …

Small‑molecule chemical drugs are of great significance for tumor‑targeted and
individualized therapies. However, the development of new small‑molecule drugs, from …

Over the past 4 decades, research has shown that having a normal body weight does not
automatically imply preserved metabolic health and a considerable number of lean …

The impacts of patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) I148M‐
rs738409, methylenetetrahydrofolate reductase (MTHFR) Ala222Val‐rs1801133, and …

Apple polyphenol extract (APE) has been reported to possess protective effects against
hepatic steatosis. To explore whether APE-induced alleviation of hepatic steatosis is SIRT1 …

An estimated 8 million people die each year from tobacco smoking, with an increasing
frequency recently being observed in Southeast Asian countries, which is a preventable risk …

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
throughout the world. Hepatocellular carcinoma (HCC) and liver cirrhosis can result from …

Background & Aims Population screening for non-alcoholic fatty liver disease (NAFLD) and
associated comorbidities remains an unaddressed clinical need. We aimed to assess the …

Gender differences in the epidemiology, pathophysiological mechanisms and clinical
features in chronic liver diseases that may be associated with type 2 diabetes (T2D) have …