Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of
human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk …

Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …

Simple Summary Despite advances in cancer treatment, difficult-to-treat tumor subtypes
remain a challenge. New multidisciplinary approaches can help overcome current obstacles …

One of the hallmarks of cancer is aberrant DNA methylation, which is associated with
abnormal gene expression. Both hypermethylation and silencing of tumour suppressor …

Objectives Paclitaxel (PTX) is frequently used in the clinical treatment of solid tumors. But the
PTX-resistance is a great obstacle in cancer treatment. Exploration of the mechanisms of …

Significant reprogramming of epigenome is widely described during pathogenesis of breast
cancer. Transformation of normal cell to hyperplastic cell and to neoplastic phenotype is …

In this research, KLA-modified liposomes co-loaded with 5-fluorouracil and paclitaxel (KLA-5-
FU/PTX Lps) were developed, and their antitumor activity against triple-negative breast …

Although soy phytoestrogens have been postulated to exert a protective effect against breast
cancer, the attendant mechanisms, in particular epigenetics underpinnings, have remained …

Breast cancer (BC) is the most common non-skin cancer and the second leading cause of
cancer death in American women. The initiation and progression of BC can proceed through …

Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic
deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant …