Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …

Microglia are the primary immune cells of the central nervous system that help nourish and
support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their …

Over 5 million Americans and 50 million individuals worldwide are living with Alzheimer's
disease (AD). The progressive dementia associated with AD currently has no cure. Although …

Introduction Nonhuman primates may serve as excellent models of sporadic age-associated
brain β-amyloid deposition and Alzheimer's disease pathologic changes. We examined …

Chronic stress has been shown to promote numerous aging-related diseases, and to
accelerate the aging process itself. Of particular interest is the impact of stress on …

Animal models are necessary tools for solving the most serious challenges facing medical
research. In aging and neurodegenerative disease studies, rodents occupy a place of …

Despite dedicated efforts to identify interventions to delay aging, most promising
interventions yielding dramatic life-span extension in animal models of aging are often …

While many preclinical models of Alzheimer's disease (AD) have been reported, none fully
recapitulate the disease. In an effort to identify an appropriate preclinical disease model, we …

DNA methylation-based biomarkers of aging have been developed for many mammals but
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …

While humans exhibit a significant degree of neuropathological changes associated with
deficits in cognitive and memory functions during aging, non‐human primates (NHP) present …