Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

Neural connectivity requires proper polarization of neurons, guidance to appropriate target
locations, and establishment of synaptic connections. From when neurons are born to when …

Background While many molecules involved in axon guidance have been identified, the
cellular and molecular mechanisms by which these molecules regulate growth cone …

Background Throughout evolution, the LIM domain has been deployed in many different
domain configurations, which has led to the formation of a large and distinct group of …

Migrating cells and growth cones extend lamellipodial and filopodial protrusions that are
required for outgrowth and guidance. The mechanisms of cytoskeletal regulation that …

The stem cell niche, a regulatory microenvironment, houses and regulates stem cells for
maintenance of tissues throughout an organism's lifespan. While it is known that stem cell …

A central step in organizing the central nervous system development is the growth cone of
an axon navigating through guidance cues to reach its specific target. While a great deal of …

LIM domain proteins display various functions including gene regulation, cell fate
determination, tumour formation and cytoskeleton organization. A diverse group of LIM …

Подавляющая часть эукариот подвержена старению, фундаментальному процессу
постепенного и приводящего к итоговой гибели организма накоплению нарушений в …

Using Drosophila actin-binding protein Dunc-115 as model system, this chapter describes a
MARCM (mosaic analysis with a repressible cell marker)-based method for analyzing …