Background Although antipsychotic maintenance treatment is widely recommended to
prevent relapse in chronic psychoses, evidence-based guidelines do not provide clear …

Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

According to current evidence and guidelines, continued antipsychotic treatment is key for
preventing relapse in people with schizophrenia‐spectrum disorders, but evidence‐based …

In recent years, machine learning (ML) has been a promising approach in the research of
treatment outcome prediction in psychosis. In this study, we reviewed ML studies using …

Abstract Background and Hypothesis There is limited evidence to guide the approaches to
clozapine treatment. Accordingly, an international initiative was undertaken with the aim of …

Alternatives to traditional categorical diagnoses have been proposed to improve the validity
and utility of psychiatric nosology. This paper continues the companion review of an …

Introduction Maintenance antipsychotic treatment improves multiple outcomes in people with
schizophrenia. These benefits are challenged by medication nonadherence, which is a …

Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …

Background Schizophrenia is a chronic mental disorder associated with substantial
morbidity and mortality affecting 0.25–1.6% of adults in the USA. Antipsychotic treatment is …

Cognitive impairment represents one of the core features of schizophrenia, involves both
neurocognition and social cognition domains, and has a significant negative impact on real …