Discovery of selective LATS inhibitors via scaffold hopping: enhancing drug-likeness and kinase selectivity for potential applications in regenerative medicine
G Issabayeva, OY Kang, SY Choi, JY Hyun… - RSC Medicinal …, 2024 - pubs.rsc.org
Due to its essential roles in cell proliferation and apoptosis, the precise regulation of the
Hippo pathway through LATS presents a viable biological target for developing new drugs …
Hippo pathway through LATS presents a viable biological target for developing new drugs …
Facile Synthesis, In silico Studies, and Biological Assessment of Novel Pyrazolo [3, 4-b] pyridine Congeners
IF Nassar, AAH Abdel-Rahman… - Egyptian Journal of …, 2024 - ejchem.journals.ekb.eg
The present work depicts synthesizing an innovative sequence of polyfunctionalized
Pyrazolo [3, 4-b] pyridine congeners 2-12 and assessed for antimicrobial, antitumor …
Pyrazolo [3, 4-b] pyridine congeners 2-12 and assessed for antimicrobial, antitumor …
Cost‐effective synthesis of unsymmetric tetrazines
J Hwang, B Yoon, SE Suh - Bulletin of the Korean Chemical …, 2024 - Wiley Online Library
Abstract 1, 2, 4, 5‐Tetrazines serve as versatile two‐carbon synthons, essential for
synthesizing a variety of (hetero) aromatic compounds. Their specific reactivity with certain …
synthesizing a variety of (hetero) aromatic compounds. Their specific reactivity with certain …