Reconstitution of the immune system after hematopoietic stem cell transplantation in humans

J Storek, M Geddes, F Khan, B Huard, C Helg… - Seminars in …, 2008 - Springer
Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a
result, the patient is at high risk of infections. Innate immunity, including epithelial barriers …

Malignancies after hematopoietic stem cell transplantation: many questions, some answers

HJ Deeg, G Socié - Blood, The Journal of the American Society …, 1998 - ashpublications.org
ALTHOUGH MANY ASPECTS of the development of malignant tumors are still incompletely
understood, conditions have been identified under which malignancies develop at a higher …

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

ME Dudley, JR Wunderlich, PF Robbins, JC Yang… - Science, 2002 - science.org
We report here the adoptive transfer, to patients with metastatic melanoma, of highly
selected tumor-reactive T cells directed against overexpressed self-derived differentiation …

Treatment of high-risk acute leukemia with T-cell–depleted stem cells from related donors with one fully mismatched HLA haplotype

F Aversa, A Tabilio, A Velardi… - … England Journal of …, 1998 - Mass Medical Soc
Background In this study we tried to achieve successful transplantation in patients with acute
leukemia with the use of hematopoietic stem cells from donors who shared only one HLA …

Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study

RE Curtis, LB Travis, PA Rowlings… - Blood, The Journal …, 1999 - ashpublications.org
We evaluated 18,014 patients who underwent allogeneic bone marrow transplantation
(BMT) at 235 centers worldwide to examine the incidence of and risk factors for …

Megadose transplantation of purified peripheral blood CD34+ progenitor cells from HLA-mismatched parental donors in children

R Handgretinger, T Klingebiel, P Lang… - Bone marrow …, 2001 - nature.com
We performed HLA-mismatched stem cell transplantation with megadoses of purified
positively selected mobilized peripheral blood CD34+ progenitor cells (PBPC) from related …

EBV/LMP-specific T cells maintain remissions of T-and B-cell EBV lymphomas after allogeneic bone marrow transplantation

LP McLaughlin, R Rouce, S Gottschalk… - Blood, The Journal …, 2018 - ashpublications.org
Autologous T cells targeting Epstein-Barr virus (EBV) latent membrane proteins (LMPs) have
shown safety and efficacy in the treatment of patients with type 2 latency EBV-associated …

Biology and adoptive cell therapy of Epstein‐Barr virus‐associated lymphoproliferative disorders in recipients of marrow allografts

RJ O'Reilly, TN Small, E Papadopoulos… - Immunological …, 1997 - Wiley Online Library
Epstein‐Barr virus (EBV) is an ubiquitous herpesvirus which is carried as a latent infection of
B lymphocytes and salivary gland epithelial cells in over 90% of normal adults. Latently …

[HTML][HTML] Place of care manufacturing of chimeric antigen receptor cells: Opportunities and challenges

RJ Orentas, B Dropulić, M de Lima - Seminars in Hematology, 2023 - Elsevier
The landscape of therapeutic options for B cell malignancies has fundamentally changed
with regulatory and marketing approval of chimeric antigen receptor (CAR)-engineered T …

In vivo B-cell depletion with rituximab for alternative donor hemopoietic SCT

A Dominietto, E Tedone, M Soracco, B Bruno… - Bone Marrow …, 2012 - nature.com
We retrospectively analyzed 55 patients given a fixed dose of rituximab (200 mg) on day+ 5
after an alternative donor transplant, to prevent EBV DNA-emia; 68 alternative transplants …