Investigating the molecular mechanisms of learning and memory using Caenorhabditis elegans

A Rahmani, YL Chew - Journal of Neurochemistry, 2021 - Wiley Online Library
Learning is an essential biological process for survival since it facilitates behavioural
plasticity in response to environmental changes. This process is mediated by a wide variety …

NPY and gene therapy for epilepsy: how, when,... and Y

S Cattaneo, G Verlengia, P Marino… - Frontiers in molecular …, 2021 - frontiersin.org
Neuropeptide Y (NPY) is a neuropeptide abundantly expressed in the mammalian central
and peripheral nervous system. NPY is a pleiotropic molecule, which influences cell …

[HTML][HTML] System-wide mapping of peptide-GPCR interactions in C. elegans

I Beets, S Zels, E Vandewyer, J Demeulemeester… - Cell reports, 2023 - cell.com
Neuropeptides and peptide hormones are ancient, widespread signaling molecules that
underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly …

Neuron-derived neuropeptide Y fine-tunes the splenic immune responses

J Yu, K Xiao, X Chen, L Deng, L Zhang, Y Li, A Gao… - Neuron, 2022 - cell.com
The nervous and immune systems are closely entwined to maintain the immune balance in
health and disease. Here, we showed that LPS can activate suprarenal and celiac ganglia …

Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair

I Aoki, L Golinelli, E Dunkel, S Bhat, E Bassam… - Nature …, 2024 - nature.com
Neuronal communication involves small-molecule transmitters, gap junctions, and
neuropeptides. While neurons often express multiple neuropeptides, our understanding of …

Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior

J Watteyne, A Chudinova, L Ripoll-Sánchez… - Genetics, 2024 - academic.oup.com
Neuropeptides are abundant signaling molecules that control neuronal activity and behavior
in all animals. Owing in part to its well-defined and compact nervous system, Caenorhabditis …

Modulating vertebrate physiology by genomic fine-tuning of GPCR functions

T Schöneberg - Physiological Reviews, 2025 - journals.physiology.org
G protein-coupled receptors (GPCRs) play a crucial role as membrane receptors, facilitating
the communication of eukaryotic species with their environment and regulating cellular and …

Phylum-spanning neuropeptide GPCR identification and prioritization: shaping drug target discovery pipelines for nematode parasite control

LE Atkinson, CJ McCoy, BA Crooks… - Frontiers in …, 2021 - frontiersin.org
Nematode parasites undermine human health and global food security. The frontline
anthelmintic portfolio used to treat parasitic nematodes is threatened by the escalation of …

NPY/NPF-related neuropeptide FLP-34 signals from serotonergic neurons to modulate aversive olfactory learning in Caenorhabditis elegans

M Fadda, N De Fruyt, C Borghgraef… - Journal of …, 2020 - Soc Neuroscience
Aversive learning is fundamental for animals to increase chances of survival. In addition to
classical neurotransmitters, neuropeptides have emerged to modulate such complex …

Signaling via the FLP-14/FRPR-19 neuropeptide pathway sustains nociceptive response to repeated noxious stimuli in C. elegans

F Marques, L Falquet, E Vandewyer, I Beets… - PLoS …, 2021 - journals.plos.org
In order to thrive in constantly changing environments, animals must adaptively respond to
threatening events. Noxious stimuli are not only processed according to their absolute …