Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Medulloblastoma (MB) is a highly malignant cerebellar tumor predominantly diagnosed
during childhood. Driven by pathogenic activation of sonic hedgehog (SHH) signaling, SHH …

Recent advances in single-cell technologies, including single-cell ATAC-seq (scATAC-seq),
have enabled large-scale profiling of the chromatin accessibility landscape at the single-cell …

The degenerative process in Parkinson's disease (PD) causes a progressive loss of
dopaminergic neurons (DaNs) in the nigrostriatal system. Resolving the differences in …

The cerebellum is the focus of an emergent series of debates because its circuitry is now
thought to encode an unexpected level of functional diversity. The flexibility that is built into …

ABSTRACT MEIS transcription factors are key regulators of embryonic development and
cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed …

Parkinson's disease (PD) is a neurodegenerative movement disorder characterized with
dopaminergic neuron (DaN) loss within the substantia nigra (SN). Despite bulk studies …

Medulloblastomas with extensive nodularity are cerebellar tumors characterized by two
distinct compartments and variable disease progression. The mechanisms governing the …

Exercise has been recognized as a beneficial factor for cognitive health, particularly in
relation to the hippocampus, a vital brain region responsible for learning and memory …