The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …

Highlights•Reviewed scoring schemes and conformational sampling for protein–protein
complex structure prediction.•Discussed the database for binding affinity of complexes and …

Recent studies found that membrane-bound K-Ras dimers are important for biological
function. However, the structure and thermodynamic stability of these complexes remained …

As an essential part of many biological processes, protein–protein interactions (PPIs) offer
exciting and promising opportunities for drug discovery by extension of the druggable target …

A decline in long-term memory (LTM) formation is a common feature of the normal aging
process, which corresponds with abnormal expression of memory-related genes in the aged …

Understanding the myriad protein–protein interactions required for cell function requires
efficient leveraging of biophysical data to drive computational docking. The detailed insight …

In view of the increasing interest both in inhibitors of protein-protein interactions and in
protein drugs themselves, analysis of the three-dimensional structure of protein-protein …

Modeling the interface region of a protein complex paves the way for understanding its
dynamics and functionalities. Existing works model the interface region of a complex by …

It is possible to accurately and economically predict change in protein-protein interaction
energy upon mutation (ΔΔG), when a high-resolution structure of the complex is available …

Protein-protein interactions regulate almost all cellular functions and rely on a fine tune of
surface amino acids properties involved on both molecular partners. The disruption of a …