Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and
pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix …

Hyaluronan (HA) is a linear polysaccharide with disaccharide repeats of d-glucuronic acid
and N-acetyl-d-glucosamine. It is evolutionarily conserved and abundantly expressed in the …

Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in
regulating inflammation. Inflammation is associated with accumulation and turnover of HA …

Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by
integral membrane synthases. The repeating sequence is perfectly homogeneous, and is …

Hyaluronan (HA) is a high molecular weight glycosaminoglycan of the extracellular matrix
(ECM), which is particularly abundant in soft connective tissues. Solutions of HA can be …

The pathological events leading to the destruction of the periodontium during inflammatory
periodontal diseases are likely to represent complex interactions involving an imbalance in …

Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and
remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix …

Hyaluronan is being used increasingly as a component of artificial matrices and in
bioengineering for tissue scaffolding. The length of hyaluronan polymer chains is now …

Breast cancer-induced inflammation in the tumor reactive stroma supports invasion and
malignant progression and is contributed to by a variety of host cells including macrophages …

Current therapies for chronic inflammatory diseases typically act through the nonspecific
downregulation of immune cell activation. However, it is becoming increasingly evident that …