Comparative pathobiology of canine and human prostate cancer: state of the art and future directions

EP Nascente, RL Amorim, CE Fonseca-Alves… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer (PC) is one of the main types of cancer that affects the
male population worldwide. In recent decades, there has been a significant evolution in the …

An RNA-Seq-based framework for characterizing canine prostate cancer and prioritizing clinically relevant biomarker candidate genes

H Thiemeyer, L Taher, JT Schille, EM Packeiser… - International journal of …, 2021 - mdpi.com
Prostate cancer (PCa) in dogs is a highly malignant disease akin to its human counterpart. In
contrast to the situation in humans, multi-gene approaches facilitating risk stratification of …

Immunohistochemical panel to characterize canine prostate carcinomas according to aberrant p63 expression

CE Fonseca-Alves, PE Kobayashi… - PloS one, 2018 - journals.plos.org
An unusual variant of prostate adenocarcinoma (PC) expressing nuclear p63 in secretory
cells instead of the typical basal expression has been reported in men. Nevertheless, the …

Comprehensive genomic profiling of androgen-receptor-negative canine prostate cancer

R Laufer-Amorim, CE Fonseca-Alves… - International Journal of …, 2019 - mdpi.com
Canine carcinomas have been considered natural models for human diseases; however,
the genomic profile of canine prostate cancers (PCs) has not been explored. In this study, 14 …

Lapatinib antitumor effect is associated with PI3K and MAPK pathway: An analysis in human and canine prostate cancer cells

CE Fonseca-Alves, AF Leis-Filho, ZA Lacerda… - Plos one, 2024 - journals.plos.org
The aberrant activation of HER2 has a pivotal role in bone metastasis implantation and
progression in several tumor types, including prostate cancer (PC). Trastuzumab and other …

Anatomy, histology, and physiology of the canine prostate gland

AF Leis-Filho, CE Fonseca-Alves - Veterinary anatomy and …, 2018 - books.google.com
The prostate gland is the only male accessory gland in dogs and is responsible for secreting
the prostatic fluid. Morphologically, the canine prostate gland lacks differentiation into zones …

Upregulated MYC expression and p53 mutations may contribute to the oncogenesis of canine Meibomian gland carcinomas

C Peterson, JL Hicks, AM De Marzo… - Veterinary …, 2023 - journals.sagepub.com
Sebaceous carcinomas of the human ocular adnexa commonly exhibit pagetoid spread,
mutations in tumor-suppressor genes, and protooncogene copy number gain. Sebaceous …

Expression and prognostic significance of vascular endothelial growth factor‐A (VEGF‐A) and its receptor in canine prostate cancer

AF Leis‐Filho, PF Lainetti, PE Kobayashi… - The …, 2021 - Wiley Online Library
Background Vascular endothelial growth factor‐A (VEGF‐A) and its receptor, VEGF receptor‐
2 (VEGFR‐2), represent a complex family of angiogenic molecules consisting of different …

Suitability of ultrasound-guided fine-needle aspiration biopsy for transcriptome sequencing of the canine prostate

H Thiemeyer, L Taher, JT Schille, L Harder… - Scientific reports, 2019 - nature.com
Ultrasound-guided fine-needle aspiration (US-FNA) biopsy is a widely used minimally
invasive sampling procedure for cytological diagnosis. This study investigates the feasibility …

Comparative Transcriptomes of Canine and Human Prostate Cancers Identify Mediators of Castration Resistance

MR Angel, B Séguin, CV Löhr, TM Beer… - Veterinary and …, 2024 - Wiley Online Library
Prostate cancer continues to be one of the most lethal cancers in men. While androgen
deprivation therapy is initially effective in treating prostate cancer, most cases of advanced …