Genetics and neurobiology of eating disorders

CM Bulik, JRI Coleman, JA Hardaway… - Nature …, 2022 - nature.com
Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …

[HTML][HTML] The impact of sugar consumption on stress driven, emotional and addictive behaviors

A Jacques, N Chaaya, K Beecher, SA Ali… - Neuroscience & …, 2019 - Elsevier
Abstract In 2016 the World Health Organization reported 39% of the world's adult population
(over 18 y) was overweight, with western countries such as Australia and the United States …

Sugar addiction: from evolution to revolution

DA Wiss, N Avena, P Rada - Frontiers in psychiatry, 2018 - frontiersin.org
The obesity epidemic has been widely publicized in the media worldwide. Investigators at all
levels have been looking for factors that have contributed to the development of this …

Long-term overconsumption of sugar starting at adolescence produces persistent hyperactivity and neurocognitive deficits in adulthood

K Beecher, I Alvarez Cooper, J Wang… - Frontiers in …, 2021 - frontiersin.org
Sugar has become embedded in modern food and beverages. This has led to
overconsumption of sugar in children, adolescents, and adults, with more than 60 countries …

A high-sugar diet consumption, metabolism and health impacts with a focus on the development of substance use disorder: a narrative review

K Witek, K Wydra, M Filip - Nutrients, 2022 - mdpi.com
Carbohydrates are important macronutrients in human and rodent diet patterns that play a
key role in crucial metabolic pathways and provide the necessary energy for proper body …

Investigating the role of GABA in neural development and disease using mice lacking GAD67 or VGAT genes

E Bolneo, PYS Chau, PG Noakes… - International journal of …, 2022 - mdpi.com
Normal development and function of the central nervous system involves a balance between
excitatory and inhibitory neurotransmission. Activity of both excitatory and inhibitory neurons …

Excessive consumption of sugar: an insatiable drive for reward

PK Olszewski, EL Wood, A Klockars, AS Levine - Current nutrition reports, 2019 - Springer
Abstract Purpose of Review Eating behavior provides energy to ensure proper functioning of
the organism. Reward aids in seeking foods that bring energy and pleasant taste, whose …

Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A …

MJ Fogarty, EWH Mu, PG Noakes, NA Lavidis… - Acta neuropathologica …, 2016 - Springer
Amyotrophic lateral sclerosis (ALS) is characterised by the death of upper (corticospinal)
and lower motor neurons (MNs) with progressive muscle weakness. This incurable disease …

Motor areas show altered dendritic structure in an amyotrophic lateral sclerosis mouse model

MJ Fogarty, EWH Mu, NA Lavidis, PG Noakes… - Frontiers in …, 2017 - frontiersin.org
Objective: Motor neurons (MNs) die in amyotrophic lateral sclerosis (ALS), a clinically
heterogeneous neurodegenerative disease of unknown etiology. In human or rodent …

Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice

JY Holgate, H Garcia, S Chatterjee… - Brain and …, 2017 - Wiley Online Library
Background Factors leading to the harmful consumption of substances, like alcohol and
sucrose, involve a complex interaction of genes and the environment. While we cannot …