The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular
damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging …

The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial
cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and …

The purpose of this Perspective is to clarify for an interdisciplinary audience the fundamental
concepts of human longevity and provide evidence for a limit to human lifespan. This …

While in the past technology has mostly been utilized to store information about the
structural configuration of proteins and molecules for research and medical purposes …

Human ageing is a complex, multifactorial process characterised by physiological damage,
increased risk of age-related diseases and inevitable functional deterioration. As the …

Purpose Medical imaging can be used to estimate a patient's biological age, which may
provide complementary information to clinicians compared to chronological age. In this …

The damage and repair of DNA is a continuous process required to maintain genomic
integrity. DNA double-strand breaks (DSBs) are the most lethal type of DNA damage and …