Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

Aims To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs)
cause atherosclerotic cardiovascular disease (ASCVD). Methods and results We assessed …

Gallstones or cholelithiasis are a major public health problem in Europe and other
developed countries and affect up to 20% of the population. Gallstone disease is the most …

Abstract Background and aims This European Atherosclerosis Society (EAS) Task Force
provides practical guidance for combination therapy for elevated low-density lipoprotein …

Genetic factors contribute importantly to the risk of coronary artery disease (CAD), and in the
past decade, there has been major progress in this area. The tools applied include genome …

Gallstone disease is a common pathology of the digestive system with nearly a 10–20%
incidence rate among adults. The mainstay of treatment is cholecystectomy, which is …

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …

Many cardiovascular diseases are facilitated by strong inheritance. For example, large-scale
genetic studies identified hundreds of genomic loci that affect the risk of coronary artery …

Except for conversion to bile salts, there is no major cholesterol degradation pathway in
mammals. Efficient excretion from the body is therefore a crucial element in cholesterol …

Importance The balance between the potential long-term clinical benefits and harms
associated with genetic cholesteryl ester transfer protein (CETP) deficiency, mimicking …