[HTML][HTML] The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease

T Hortobágyi, T Vetrovsky, GM Balbim… - Ageing Research …, 2022 - Elsevier
Objective To determine the effects of low-vs. high-intensity aerobic and resistance training
on motor and cognitive function, brain activation, brain structure, and neurochemical …

Effects of exercise training on nigrostriatal neuroprotection in Parkinson's disease: a systematic review

S Ishaq, IA Shah, SD Lee, BT Wu - Frontiers in Neuroscience, 2025 - frontiersin.org
Introduction Parkinson's disease (PD) is characterized by progressive neurodegeneration
within the nigrostriatum, leading to motor dysfunction. This systematic review aimed to …

Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson's disease

B de Laat, J Hoye, G Stanley, M Hespeler, J Ligi… - npj Parkinson's …, 2024 - nature.com
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons.
Exercise has been reported to slow the clinical progression of PD. We evaluated the …

Targeting macroautophagy as a therapeutic opportunity to treat Parkinson's disease

I Sanchez-Mirasierra, S Ghimire… - Frontiers in Cell and …, 2022 - frontiersin.org
Macroautophagy, an evolutionary conserved catabolic process in the eukaryotic cell,
regulates cellular homeostasis and plays a decisive role in self-engulfing proteins, protein …

The transient receptor potential melastatin 2: a new therapeutical target for Parkinson's disease?

AFF Ferreira, LRG Britto - Neural Regeneration Research, 2023 - journals.lww.com
The transient receptor potential melastatin 2 is a calcium-permeable cation channel member
of the TRP family. Also known as an oxidative stress-activated channel, the transient …

RAGE: a potential target for Epimedium's anti-neuroinflammation role in vascular dementia—insights from network pharmacology and molecular simulation

P Yuan, W Chen, X Wang, L Li, Z Peng… - Journal of …, 2024 - Taylor & Francis
Vascular dementia (VaD), a cognitive impairment resulting from cerebrovascular issues,
could be mitigated by Epimedium. This study investigates Epimedium's efficacy in VaD …

[HTML][HTML] Most utilized rodent models for Alzheimer's and Parkinson's disease: A critical review of the past 5 years

AFF Ferreira, M Meira, LM Lemuchi… - Advanced …, 2024 - accscience.com
The past few years have witnessed extensive research on the two most common
neurodegenerative diseases, Alzheimer's disease (AD), and Parkinson's disease (PD). With …

Selecting the Best Animal Model of Parkinson's Disease for Your Research Purpose: Insight from in vivo PET Imaging Studies

CC Real, KH Binda, MB Thomsen… - Current …, 2023 - benthamdirect.com
Parkinson's disease (PD) is a debilitating neurodegenerative multisystem disorder leading
to motor and non-motor symptoms in millions of individuals. Despite intense research, there …

Effects and parameters of community-based exercise on motor symptoms in Parkinson's disease: a meta-analysis

CL Yang, JP Huang, TT Wang, YC Tan, Y Chen… - BMC neurology, 2022 - Springer
Background Community-based exercise is a continuation and complement to inpatient
rehabilitation for Parkinson's disease and does not require a professional physical therapist …

HIF-1 signalling pathway was identified as a potential new pathway for Icariin's treatment against Alzheimer's disease based on preclinical evidence and …

M You, P Yuan, L Li, H Xu - Frontiers in Pharmacology, 2022 - frontiersin.org
Aim: Alzheimer's disease (AD) is a neurodegenerative condition that is characterized by the
gradual loss of memory and cognitive function. Icariin, which is a natural chemical isolated …