This review focuses on fibrin, starting from biological mechanisms (its production from
fibrinogen and its enzymatic degradation), through its use as a medical device and as a …

Type I collagen and fibrin are two essential proteins in tissue regeneration and have been
widely used for the design of biomaterials. While they both form hydrogels via fibrillogenesis …

Multiscale mechanical models in biomaterials research have largely relied on simplifying the
microstructure in order to make large-scale simulations tractable. The microscale …

In innervated collagenous tissues, tissue scale loading may contribute to joint pain by
transmitting force through collagen fibers to the embedded mechanosensitive axons …

Tunable mechanics and fracture resistance are hallmarks of biological tissues whose
properties arise from extracellular matrices comprised of double networks. To elucidate the …

Collagen networks contribute to tissue architecture and modulate cellular responses in
crowded three-dimensional environments. Therefore, it is the most widely used biological …

The myotendinous junction transfers forces from muscle to tendon. As such, it must hold two
tissues of completely different biological and cellular compositions as well as mechanical …

Fibrin-Type I collagen composite gels have been widely studied as biomaterials, in which
both networks are usually formed simultaneously at a neutral pH. Here, we describe a new …

Emergent properties of cells and tissues in health and disease Page 1 Emergent properties of
cells and tissues in health and disease Ph.D. Degree Dissertation Pancy T. Lwin May 18, 2023 …

The microstructure of the extracellular matrix (ECM) plays a key role in affecting cell
migration, especially nonproteolytic migration. It is difficult, however, to measure some …