Technical innovations in peritoneal dialysis (PD), now used widely for the long-term
treatment of ESRD, have significantly reduced therapy-related complications, allowing …

Long-term peritoneal dialysis can lead to morphological and functional changes in the
peritoneum. Although the range of morphological alterations is known for the peritoneal …

Systemic inflammation, as evidenced by elevated inflammatory cytokines, is a feature of
advanced renal failure and predicts worse survival. Dialysate IL-6 concentrations associate …

Abstract Interleukin (IL)-6 has become a major target for clinical intervention in various
autoimmune conditions. Here, drugs including the humanized anti-IL-6 receptor (IL-6R) …

Vascular endothelial growth factor (VEGF) is implicated in the peritoneal membrane
remodeling that limits ultrafiltration in patients on peritoneal dialysis (PD). Although the exact …

Peritoneal dialysis (PD) has achieved its current position as the most commonly used home-
based dialysis therapy—and with patient survival equal to that seen with hemodialysis …

Long-term peritoneal dialysis is associated with alterations in peritoneal function, like the
development of high small solute transfer rates and impaired ultrafiltration. Also …

High salt intake is a primary cause of over-hydration in chronic kidney disease (CKD)
patients. Inflammatory markers are predictors of CKD mortality; however, the pathogenesis …

Long-term peritoneal dialysis (PD) therapy results in functional and structural alteration of
the peritoneal membrane, including epithelial-to-mesenchymal transition (EMT). Interleukin …

Changes to peritoneal membrane function over time result in the development of
ultrafiltration failure in a proportion of PD patients and pose a risk for the rarer condition of …