Aspects of the tumor microenvironment involved in immune resistance and drug resistance

K Khalaf, D Hana, JTT Chou, C Singh… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Mesothelial-to-mesenchymal transition and exosomes in peritoneal metastasis of ovarian cancer

L Pascual-Antón, B Cardeñes… - International journal of …, 2021 - mdpi.com
Most patients with ovarian cancer (OvCA) present peritoneal disseminated disease at the
time of diagnosis. During peritoneal metastasis, cancer cells detach from the primary tumor …

[HTML][HTML] Tumor-derived extracellular vesicles promote activation of carcinoma-associated fibroblasts and facilitate invasion and metastasis of ovarian cancer by …

Y Cui, D Wang, M Xie - Frontiers in cell and developmental …, 2021 - pmc.ncbi.nlm.nih.gov
Ovarian cancer (OC) is a lethal gynecological malignancy. Extracellular vesicles (EVs) are
crucial media in cell-to-cell communication by carrying microRNAs (miRs). The current study …

Ovarian cancer: biomarkers and targeted therapy

MR Radu, A Prădatu, F Duică, R Micu, SM Creţoiu… - Biomedicines, 2021 - mdpi.com
Ovarian cancer is one of the most common causes of death in women as survival is highly
dependent on the stage of the disease. Ovarian cancer is typically diagnosed in the late …

Extracellular vesicles-ceRNAs as ovarian cancer biomarkers: looking into circRNA-miRNA-mRNA code

G Cammarata, N Barraco, I Giusti, V Gristina, V Dolo… - Cancers, 2022 - mdpi.com
Simple Summary Patients with ovarian cancer have a very poor chance of long-term
survival, usually due to advanced disease at the time of diagnosis. Emerging evidence …

Curcumin modulates cell type-specific miRNA networks to induce cytotoxicity in ovarian cancer cells

F Ravindran, A Mhatre, J Koroth, S Narayan… - Life Sciences, 2023 - Elsevier
Aim To understand the epigenetic role of curcumin, a natural polyphenolic compound
extracted from the spice Curcuma longa in inducing cytotoxicity in two molecularly distinct …

The miRNA-21-5p payload in exosomes from M2 macrophages drives tumor cell aggression via PTEN/Akt signaling in renal cell carcinoma

Z Zhang, J Hu, M Ishihara, AC Sharrow, K Flora… - International Journal of …, 2022 - mdpi.com
M2 macrophages in the tumor microenvironment are important drivers of cancer metastasis.
Exosomes play a critical role in the crosstalk between different cells by delivering …

NF-κB signaling modulates miR-452-5p and miR-335-5p expression to functionally decrease epithelial ovarian cancer progression in tumor-initiating cells

RD Kamdar, BS Harrington, E Attar, S Korrapati… - International Journal of …, 2023 - mdpi.com
Epithelial ovarian cancer (EOC) remains the fifth leading cause of cancer-related death in
women worldwide, partly due to the survival of chemoresistant, stem-like tumor-initiating …

Circular RNAs in epithelial ovarian cancer: from biomarkers to therapeutic targets

Y Qiu, Y Chen, O Agbede, E Eshaghi, C Peng - Cancers, 2022 - mdpi.com
Simple Summary Epithelial ovarian cancer (EOC) is the deadliest cancer in the female
reproductive system. Currently, there are no effective early detection methods for this …

Inhibition of CDK1 by RO-3306 exhibits anti-tumorigenic effects in ovarian cancer cells and a transgenic mouse model of ovarian cancer

Y Huang, Y Fan, Z Zhao, X Zhang, K Tucker… - International journal of …, 2023 - mdpi.com
Ovarian cancer is the deadliest gynecological malignancy of the reproductive organs in the
United States. Cyclin-dependent kinase 1 (CDK1) is an important cell cycle regulatory …