Physical factors in the local cellular microenvironment, including cell shape and geometry,
matrix mechanics, external mechanical forces, and nanotopographical features of the …

The functionality of stem cells is tightly regulated by cues from the niche, comprising both
intrinsic and extrinsic cell signals. Besides chemical and growth factors, biophysical signals …

There is a continuing need for artificial bone substitutes for bone repair and reconstruction,
Magnesium phosphate bone cement (MPC) has exceptional degradable properties and …

Abstract Background Deregulation of Wnt/β-catenin signaling is a hallmark of the majority of
sporadic forms of colorectal cancer and results in increased stability of the protein β-catenin …

Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory
and oncology indications, including ulcerative colitis and colorectal cancer. MMP9 is a …

Activation of the Wnt signaling pathway via mutation of the adenomatous polyposis coli gene
(APC) is a critical event in the development of colon cancer. For colon carcinogenesis …

N-cadherin, a transmembrane protein and major component of adherens junction, mediates
cell-cell interactions and intracellular signaling that are important to the regulation of cell …

Embryonic lung development requires reciprocal endodermal-mesodermal interactions;
mediated by various signaling proteins. Wnt/β-catenin is a signaling protein that exhibits the …

Characterized by the hardening of arteries, vascular calcification is the deposition of
hydroxyapatite crystals in the arterial tissue. Calcification is now understood to be a cell …

Epithelial to mesenchymal transition (EMT), the process during which epithelial cells lose
adhesions with neighbouring cells and get converted to migratory and invasive cells, is …