Background The widespread use of immune checkpoint inhibitors (ICIs) has revolutionised
treatment of multiple cancer types. However, selecting patients who may benefit from ICI …

Tumor immune microenvironment (TIME) consists of intra-tumor immunological components
and plays a significant role in tumor initiation, progression, metastasis, and response to …

Despite the remarkable success of anti-cancer immunotherapy, its effectiveness remains
confined to a subset of patients—emphasizing the importance of predictive biomarkers in …

Simple Summary Although the incorporation of immune checkpoint inhibitors (ICIs) in
melanoma treatment has significantly improved prognosis for patients with advanced …

Resistance to genotoxic therapies and tumor recurrence are hallmarks of glioblastoma
(GBM), an aggressive brain tumor. In this study, we investigated functional drivers of post …

Progress in sequencing technologies and clinical experiments has revolutionized
immunotherapy on solid and hematologic malignancies. However, the benefits of …

Approximately 15% of locally advanced colorectal cancers (CRC) have DNA mismatch
repair deficiency (dMMR), resulting in high microsatellite instability and a high tumour …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

Introduction Growing interest toward RNA modification in cancer has inspired the
exploration of gene sets related to multiple RNA modifications. However, a comprehensive …

Background Previous studies have traditionally attributed the initiation of cancer cells to
genetic mutations, considering them as the fundamental drivers of carcinogenesis. However …