Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

This article describes the critical role of neurosteroids in postpartum depression (PPD) and
outlines the landmark pharmacological journey of brexanolone as a first-in-class …

In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone
were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABA A …

Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the
hypothalamus is implicated in energy balance control and memory disorders, we …

Perinatal depression is a mood disorder that is reported in women during pregnancy
(prenatal) and after childbirth (postnatal). The onset of perinatal depression is associated …

Anxiety and stress-related disorders are more prevalent in women and associated with
negative emotional memory consolidation as well as impaired fear extinction recall. Recent …

Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. The level of
exposure to nanosilver is constantly raising, and a growing body of research highlights that it …

Fibromyalgia (FM) is a central disorder characterized by chronic pain, fatigue, insomnia,
depression, and other minor symptoms. Knowledge about pathogenesis is lacking …

The central nervous system (CNS) is an important pharmacological target, but it is very
effectively protected by the blood–brain barrier (BBB), thereby impairing the efficacy of many …