New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures

AL Boxer, M Gold, H Feldman, BF Boeve… - Alzheimer's & …, 2019 - Elsevier
Introduction Frontotemporal lobar degeneration (FTLD) is the most common form of
dementia for those under 60 years of age. Increasing numbers of therapeutics targeting …

Consensus-based technical recommendations for clinical translation of renal ASL MRI

F Nery, CE Buchanan, AA Harteveld, A Odudu… - … Resonance Materials in …, 2020 - Springer
Objectives This study aimed at developing technical recommendations for the acquisition,
processing and analysis of renal ASL data in the human kidney at 1.5 T and 3 T field …

Value-generating exploratory trials in neurodegenerative dementias

LG Friedman, N McKeehan, Y Hara, JL Cummings… - Neurology, 2021 - AAN Enterprises
Drug development for Alzheimer disease and other neurodegenerative dementias, including
frontotemporal dementia, has experienced a long history of phase 2 and phase 3 clinical …

[HTML][HTML] ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies

HJMM Mutsaerts, J Petr, P Groot, P Vandemaele… - Neuroimage, 2020 - Elsevier
Arterial spin labeling (ASL) has undergone significant development since its inception, with
a focus on improving standardization and reproducibility of its acquisition and quantification …

The effects of age on resting‐state BOLD signal variability is explained by cardiovascular and cerebrovascular factors

KA Tsvetanov, RNA Henson, PS Jones… - …, 2021 - Wiley Online Library
Accurate identification of brain function is necessary to understand neurocognitive aging,
and thereby promote health and well‐being. Many studies of neurocognitive aging have …

Cerebral blood flow changes after a day of wake, sleep, and sleep deprivation

T Elvsåshagen, HJ Mutsaerts, N Zak, LB Norbom… - NeuroImage, 2019 - Elsevier
Elucidating the neurobiological effects of sleep and wake is an important goal of the
neurosciences. Whether and how human cerebral blood flow (CBF) changes during the …

Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study

HJMM Mutsaerts, SS Mirza, J Petr, DL Thomas… - Brain, 2019 - academic.oup.com
Genetic forms of frontotemporal dementia are most commonly due to mutations in three
genes, C9orf72, GRN or MAPT, with presymptomatic carriers from families representing …

The association between frailty and MRI features of cerebral small vessel disease

IMJ Kant, HJMM Mutsaerts, SJT van Montfort… - Scientific reports, 2019 - nature.com
Frailty is a common syndrome in older individuals that is associated with poor cognitive
outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to …

Accurate MR image registration to anatomical reference space for diffuse glioma

M Visser, J Petr, DMJ Müller, RS Eijgelaar… - Frontiers in …, 2020 - frontiersin.org
To summarize the distribution of glioma location within a patient population, registration of
individual MR images to anatomical reference space is required. In this study, we quantified …

Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion

DA Ferro, HJJM Mutsaerts, S Hilal… - Journal of Cerebral …, 2020 - journals.sagepub.com
Cerebral cortical microinfarcts (CMIs) are small ischemic lesions associated with cognitive
impairment and dementia. CMIs are frequently observed in cortical watershed areas …