Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …

One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

The appearance of alpha-synuclein-positive inclusion bodies (Lewy bodies) and the loss of
catecholaminergic neurons are the primary pathological hallmarks of Parkinson's disease …

α-Synuclein (α-syn), a small highly conserved presynaptic protein containing 140 amino
acids, is thought to be the main pathological hallmark in related neurodegenerative …

Posttranslational modifications are ubiquitous regulators of cellular processes. The
regulatory role of SUMOylation, the attachment of a small ubiquitin-related modifier to a …

Epilepsy is caused when rhythmic neuronal network activity escapes normal control
mechanisms, resulting in seizures. There is an extensive and growing body of evidence that …

Background. Zinc plays a role in mitophagy and protects cardiomyocytes from
ischemia/reperfusion injury. This study is aimed at investigating whether SUMOylation of …

Neuronal lesions in Parkinson's disease (PD) are commonly associated with α-synuclein (α-
Syn)-induced cell damage that are present both in the central and peripheral nervous …

Abstract The Fragile X Mental Retardation Protein (FMRP) is an RNA-binding protein
essential to the regulation of local translation at synapses. In the mammalian brain …