Health functions and structure–activity relationships of natural anthraquinones from plants

Y Li, JG Jiang - Food & function, 2018 - pubs.rsc.org
Anthraquinone compounds with the anthraquinone ring structure are widely found in
traditional Chinese medicines and they are attracting a lot of attention due to their good …

Plant anthraquinones: classification, distribution, biosynthesis, and regulation

P Wang, J Wei, X Hua, G Dong… - Journal of Cellular …, 2024 - Wiley Online Library
Anthraquinones are polycyclic compounds with an unsaturated diketone structure (quinoid
moiety). As important secondary metabolites of plants, anthraquinones play an important …

Compounds from natural sources as protein kinase inhibitors

A Baier, R Szyszka - Biomolecules, 2020 - mdpi.com
The advantage of natural compounds is their lower number of side-effects when compared
to most synthetic substances. Therefore, over the past several decades, the interest in …

Plasmodial kinase inhibitors: license to cure?

DG Cabrera, A Horatscheck, CR Wilson… - Journal of Medicinal …, 2018 - ACS Publications
Advances in the genetics, function, and stage-specificity of Plasmodium kinases has driven
robust efforts to identify targets for the design of antimalarial therapies. Reverse genomics …

Botanical medicines Cryptolepis sanguinolenta, Artemisia annua, Scutellaria baicalensis, Polygonum cuspidatum, and Alchornea cordifolia demonstrate inhibitory …

Y Zhang, H Alvarez-Manzo, J Leone… - Frontiers in Cellular …, 2021 - frontiersin.org
Human babesiosis is a CDC reportable disease in the United States and is recognized as
an emerging health risk in multiple parts of the world. The current treatment for human …

Plasmodial kinase inhibitors targeting malaria: recent developments

R Mustière, P Vanelle, N Primas - Molecules, 2020 - mdpi.com
Recent progress in reducing malaria cases and ensuing deaths is threatened by factors like
mutations that induce resistance to artemisinin derivatives. Multiple drugs are currently in …

Hybrid molecules based on an emodin scaffold. Synthesis and activity against SARS-CoV-2 and Plasmodium

Y Li, F Touret, X de Lamballerie, M Nguyen… - Organic & …, 2023 - pubs.rsc.org
Since the Covid-19 epidemic, it has been clear that the availability of small and affordable
drugs that are able to efficiently control viral infections in humans is still a challenge in …

Recent advances on discovery of enzyme inhibitors from natural products using bioactivity screening

TC Yan, J Cao, LH Ye - Journal of Separation Science, 2022 - Wiley Online Library
The essence of enzymes is to keep the homeostasis and balance of humans by catalyzing
metabolic responses and modulating cells. Suppression of an enzyme slows the progress of …

Antiplasmodial anthraquinones from medicinal plants: the chemistry and possible mode of actions

CP Osman, NH Ismail - Natural Product Communications, 2018 - journals.sagepub.com
Malaria killed nearly half a million people in 2015, and 70% of this victims were young
children. Malarial chemotherapy makes use of several drugs, each with its own …

An update on development of small-molecule Plasmodial kinase inhibitors

C Moolman, R Sluis, RM Beteck, LJ Legoabe - Molecules, 2020 - mdpi.com
Malaria control relies heavily on the small number of existing antimalarial drugs. However,
recurring antimalarial drug resistance necessitates the continual generation of new …