Inflammation is emerging as one of the hallmarks of cancer, yet its role in most tumors
remains unclear. Whereas a minority of solid tumors are associated with overt inflammation …

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and
pathological conditions. It is also one of the most studied topics among cell biologists. An …

Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are
common in diverse types of human cancer. The p53 mutational spectrum differs among …

Colon carcinoma is the second most common cause of death from cancer. The isolation and
characterization of tumorigenic colon cancer cells may help to devise novel diagnostic and …

The development of cancer is due to the accumulation of multiple somatic mutations and in
some cases due to germline mutations, which occur in malignancies such as retinoblastoma …

The cell cycle is composed of a series of steps which can be negatively or postively
regulated by various factors. Chief among the negative regulators is the p53 protein …

It has long been considered that genetic instability is an integral component of human
neoplasia1–3. In a small fraction of tumours, mismatch repair deficiency leads to a …

A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in
some families. Molecular features of" familial" cancers were compared with those of sporadic …

MULTIPLE endocrine neoplasia type 2A (MEN 2A) is a dominantly inherited cancer
syndrome that affects tissues derived from neural ectoderm. It is characterized by medullary …

Genistein is a soy derived isoflavanoid compound with multitude of health benefits. This
compound is found to be a potent agent in both prophylaxis and treatment of cancer and …