Natural-product-inspired microwave-assisted synthesis of novel spirooxindoles as antileishmanial agents: synthesis, stereochemical assignment, bioevaluation, SAR …
NK Sahu, R Sharma, KP Suhas, J Joshi, K Prakash… - Molecules, 2023 - mdpi.com
Leishmaniasis is a neglected tropical disease, and there is an emerging need for the
development of effective drugs to treat it. To identify novel compounds with antileishmanial …
development of effective drugs to treat it. To identify novel compounds with antileishmanial …
TDP1 phosphorylation by CDK1 in mitosis promotes MUS81-dependent repair of trapped Top1-DNA covalent complexes
S Paul Chowdhuri, BB Das - The EMBO Journal, 2024 - embopress.org
Abstract Topoisomerase 1 (Top1) controls DNA topology, relieves DNA supercoiling during
replication and transcription, and is critical for mitotic progression to the G1 phase. Tyrosyl …
replication and transcription, and is critical for mitotic progression to the G1 phase. Tyrosyl …
Sojourn of Nitrogenous Heterocycles as Promising Antileishmanial Agents: Medicinal Perspectives and Structure–Activity Relationship Studies
Leishmania is a protozoal parasitic disease enlisted in neglected disease by World Health
Organization (WHO) and caused by different leishmanial species. Due to the adverse-effects …
Organization (WHO) and caused by different leishmanial species. Due to the adverse-effects …
[HTML][HTML] Fluorescence-resonance-energy-transfer-based assay to estimate modulation of TDP1 activity through arginine methylation
Tyrosyl DNA phosphodiesterase (TDP1) is a DNA repair enzyme that hydrolyzes the
phosphotyrosyl linkage between 3′-DNA-protein crosslinks such as stalled topoisomerase …
phosphotyrosyl linkage between 3′-DNA-protein crosslinks such as stalled topoisomerase …