CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however,
these drugs must enter the desired cell without eliciting an unwanted immune response, so …

In the past decade, nucleic acid therapies have seen a boon in development and clinical
translation largely due to advances in nanotechnology that have enabled their safe and …

Engineered T cells expressing chimeric antigen receptors (CARs) have been proven as
efficacious therapies against selected hematological malignancies. However, the approved …

With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid
(mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention …

Lipid nanoparticles (LNPs) have proven themselves as transformative actors in chimeric
antigen receptor (CAR) T cell therapy, surpassing traditional methods and addressing …

Lipid nanoparticles (LNPs) have emerged as an effective and promising technology for
messenger RNA (mRNA) delivery, offering a potential solution to physiological barriers and …

Colorectal cancer (CRC) is a common type of gastrointestinal tract (GIT) cancer and poses
an enormous threat to human health. Current strategies for metastatic colorectal cancer …

RNA therapeutics, such as mRNA, siRNA, and CRISPR–Cas9, present exciting avenues for
treating diverse diseases. However, their potential is commonly hindered by vulnerability to …

Autoimmune disorders have risen to be among the most prevalent chronic diseases across
the globe, affecting approximately 5–7% of the population. As autoimmune diseases steadily …

Engineering and reprogramming cells has significant therapeutic potential to treat a wide
range of diseases, by replacing missing or defective proteins, to provide transcription factors …