Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …

Originally regarded as just membrane constituents and energy storing molecules, lipids are
now recognised as potent signalling molecules that regulate a multitude of cellular …

Before we discuss lipids and their role in homeostasis and host defense, we will recount the
essence of the inflammatory response. Inflammation is a reaction of the microcirculation; it's …

Treatment of tuberculosis (TB) remains challenging, with lengthy treatment durations and
complex drug regimens that are toxic and difficult to administer. Similar to the vast majority of …

Bioactive lipids regulate most physiological processes, from digestion to blood flow and from
hemostasis to labor. Lipid mediators are also involved in multiple pathologies including …

Sepsis, trauma, burns, and major surgical procedures activate common systemic
inflammatory pathways. Nosocomial infection, organ failure, and mortality in this patient …

Macrophages are professional phagocytes at the front line of immune defenses against
foreign bodies and microbial pathogens. Various bacteria, which are responsible for deadly …

Background Pulmonary infection of humans by Mycobacterium tuberculosis (Mtb), the
causative agent of tuberculosis (TB), results in active disease in 5-10% of individuals, while …

Chitosan biocompatibility and mucoadhesiveness make it an ideal polymer for
antituberculotic drugs microcapsulation for pulmonary delivery. Yet, previous study indicated …

Abstract The 5-lipoxygenase (ALOX5)-derived lipid mediators leukotrienes and lipoxins
have regulatory functions in inflammation by modulating activities of immune cells and …