Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all
BA Desimmie, KA Delviks-Frankenberrry… - Journal of molecular …, 2014 - Elsevier
Several members of the APOBEC3 family of cellular restriction factors provide intrinsic
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
Suppression of APOBEC3-mediated restriction of HIV-1 by Vif
The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F
KK Siu, A Sultana, FC Azimi, JE Lee - Nature communications, 2013 - nature.com
The human APOBEC3 family of DNA cytosine deaminases serves as a front-line intrinsic
immune response to inhibit the replication of diverse retroviruses. APOBEC3F and …
immune response to inhibit the replication of diverse retroviruses. APOBEC3F and …
Dodging the host interferon-stimulated gene mediated innate immunity by HIV-1: a brief update on intrinsic mechanisms and counter-mechanisms
K Chintala, K Mohareer, S Banerjee - Frontiers in Immunology, 2021 - frontiersin.org
Host restriction factors affect different phases of a viral life cycle, contributing to innate
immunity as the first line of defense against viruses, including HIV-1. These restriction factors …
immunity as the first line of defense against viruses, including HIV-1. These restriction factors …
Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B
The single-stranded DNA cytidine deaminases APOBEC3B, APOBEC3H haplotype I, and
APOBEC3A can contribute to cancer through deamination of cytosine to form promutagenic …
APOBEC3A can contribute to cancer through deamination of cytosine to form promutagenic …
Structure-guided analysis of the human APOBEC3-HIV restrictome
H Aydin, MW Taylor, JE Lee - Structure, 2014 - cell.com
Human APOBEC3 (A3) proteins are host-encoded intrinsic restriction factors that inhibit the
replication of many retroviral pathogens. Restriction is believed to occur as a result of the …
replication of many retroviral pathogens. Restriction is believed to occur as a result of the …
Different mutagenic potential of HIV-1 restriction factors APOBEC3G and APOBEC3F is determined by distinct single-stranded DNA scanning mechanisms
The APOBEC3 deoxycytidine deaminase family functions as host restriction factors that can
block replication of Vif (virus infectivity factor) deficient HIV-1 virions to differing degrees by …
block replication of Vif (virus infectivity factor) deficient HIV-1 virions to differing degrees by …
Degradation-independent inhibition of APOBEC3G by the HIV-1 Vif protein
B Stupfler, C Verriez, S Gallois-Montbrun, R Marquet… - Viruses, 2021 - mdpi.com
The ubiquitin–proteasome system plays an important role in the cell under normal
physiological conditions but also during viral infections. Indeed, many auxiliary proteins from …
physiological conditions but also during viral infections. Indeed, many auxiliary proteins from …
Examination of the APOBEC3 barrier to cross species transmission of primate lentiviruses
The transmission of viruses from animal hosts into humans have led to the emergence of
several diseases. Usually these cross-species transmissions are blocked by host restriction …
several diseases. Usually these cross-species transmissions are blocked by host restriction …
Mechanism of enhanced HIV restriction by virion coencapsidated cytidine deaminases APOBEC3F and APOBEC3G
ABSTRACT The APOBEC3 (A3) enzymes, A3G and A3F, are coordinately expressed in
CD4+ T cells and can become coencapsidated into HIV-1 virions, primarily in the absence of …
CD4+ T cells and can become coencapsidated into HIV-1 virions, primarily in the absence of …