The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease is a common and devastating disease characterized by aggregation of
the amyloid-β peptide. However, we know relatively little about the underlying molecular …

The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We
previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We …

Transient soluble oligomers of amyloid-β (Aβ) are toxic and accumulate early prior to
insoluble plaque formation and cognitive impairment in Alzheimer's disease (AD). Synthetic …

Disruption of mitochondrial function and protein homeostasis plays a central role in aging.
However, how these processes interact and what governs their failure in aging remain …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in
Alzheimer's disease (AD). The use of chemical kinetics has recently enabled highly accurate …

The conversion of the β-amyloid (Aβ) peptide into pathogenic aggregates is linked to the
onset and progression of Alzheimer's disease. Although this observation has prompted an …