Although phenomenlogical models that account for cooperativity in allosteric systems date
back to the early and mid‐60's (eg, the KNF and MWC models), there is resurgent interest in …

Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …

Allostery has come of age; the number, breadth and functional roles of documented
proteinallostery cases are rising quickly. Since all dynamic proteins are potentially allosteric …

Allostery describes altered protein function at one site due to a perturbation at another site.
One mechanism of allostery involves correlated motions, which can occur even in the …

Protein function and dynamics are closely related; however, accurate dynamics information
is difficult to obtain. Here based on a carefully assembled data set derived from experimental …

The community structure–activity resource (CSAR) data sets are used to develop and test a
support vector machine-based scoring function in regression mode (SVR). Two scoring …

Nuclear magnetic resonance (NMR) spectroscopy provides a unique toolbox of
experimental probes for studying dynamic processes on a wide range of timescales, ranging …

A dense interplay between structure and dynamics underlies the working of proteins,
especially enzymes. Protein kinases are molecular switches that are optimized for their …

Understanding how allosteric proteins respond to changes in their environment is a major
goal of current biological research. We show that these responses can be quantified by …