Development and functional diversification of cortical interneurons

L Lim, D Mi, A Llorca, O Marín - Neuron, 2018 - cell.com
In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …

New insights into the development of the human cerebral cortex

Z Molnár, GJ Clowry, N Šestan, A Alzu'bi… - Journal of …, 2019 - Wiley Online Library
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution

CA Herring, RK Simmons, S Freytag, D Poppe… - Cell, 2022 - cell.com
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …

Human 3D cellular model of hypoxic brain injury of prematurity

AM Pașca, JY Park, HW Shin, Q Qi, O Revah… - Nature medicine, 2019 - nature.com
Owing to recent medical and technological advances in neonatal care, infants born
extremely premature have increased survival rates,. After birth, these infants are at high risk …

Cortical malformations: lessons in human brain development

L Subramanian, ME Calcagnotto… - Frontiers in cellular …, 2020 - frontiersin.org
Creating a functional cerebral cortex requires a series of complex and well-coordinated
developmental steps. These steps have evolved across species with the emergence of …

Human cerebral organoids—a new tool for clinical neurology research

OL Eichmüller, JA Knoblich - Nature Reviews Neurology, 2022 - nature.com
The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Therapeutic plasticity of neural stem cells

L Ottoboni, B von Wunster, G Martino - Frontiers in neurology, 2020 - frontiersin.org
Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …

Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain

C Chung, X Yang, RF Hevner, K Kennedy, KI Vong… - Nature, 2024 - nature.com
Debate remains around the anatomical origins of specific brain cell subtypes and lineage
relationships within the human forebrain,,,,,–. Thus, direct observation in the mature human …

Brain size and limits to adult neurogenesis

MF Paredes, SF Sorrells… - Journal of …, 2016 - Wiley Online Library
The walls of the cerebral ventricles in the developing embryo harbor the primary neural stem
cells from which most neurons and glia derive. In many vertebrates, neurogenesis continues …

[HTML][HTML] Human models are needed for studying human neurodevelopmental disorders

X Zhao, A Bhattacharyya - The American Journal of Human Genetics, 2018 - cell.com
The analysis of animal models of neurological disease has been instrumental in furthering
our understanding of neurodevelopment and brain diseases. However, animal models are …